Table E6.
Factors associated with greater severity of coronary artery stenosis
| Factor | Coefficient ± SE | P value |
|---|---|---|
| Coronary-level variables | ||
| Anomalous origin | 0.029 ± 0.071 | .8 |
| Patient-level variables | ||
| Anomalous coronary: LCx | 1.0 ± 0.11 | <.0001 |
| Male | 0.92 ± 0.13 | <.0001 |
| Older age∗ | 1.1 ± 0.10 | <.0001 |
| Diabetes | 0.41 ± 0.14 | .004 |
| Peripheral artery disease | 0.57 ± 0.18 | .002 |
| Tobacco use | 0.37 ± 0.11 | .0006 |
| Hypertension (lower risk) | −0.27 ± 0.12 | .02 |
| Congestive heart failure (less risk) | −0.33 ± 0.15 | .02 |
| Pulmonary disease (lower risk) | −0.96 ± 0.17 | <.0001 |
Using the 4 coronary stenosis measurements as a patient-cluster response and cumulative logistic mixed-effects model, associations with the presence of an anomalous coronary, demographics, and comorbidities were considered. The presence of an anomalous origin did not increase the likelihood of greater CAD severity. At the patient level, the presence of anomalous LCx increased the severity of CAD in all coronary arteries (with and without anomalous origins). SE, Standard error; LCx, left circumflex; CAD, coronary artery disease.
∗
[Age/50]2, squared transformation.