FIG 1.

PDAC-intrinsic immunoevasive properties. APC, antigen-presenting cell; CAF, cancer-associated fibroblasts; DC, dendritic cell; GM-CSF, granulocyte-macrophage colony-stimulating factor; HLA-DR, human leukocyte antigen-DR isotype; IDO, indoleamine 2,3-dioxygenase; IL, interleukin; KYN, kynurenine; MDSCs, myeloid-derived suppressor cells; MHC-1, major histocompatibility complex-1; PD-1, programmed death-1; PDAC, pancreatic adenocarcinoma; PD-L1, programmed death ligand-1; SIRPα, signal regulatory protein alpha; TAM, tumor-associated macrophages; TCR, T-cell receptor; Treg, regulatory T-cell; TRP, tryptophan.