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. 2022 Feb 10;2(2):78–89. doi: 10.1158/2767-9764.CRC-21-0146

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© 2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.

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Cellular criteria required for TCCN definition (A). Derivation of study-specific 50-μm-diameter TCCN size based on number of neighborhoods satisfying cell and nonoverlapping criteria across various radius sizes (0–60 μm; B). Stepwise derivation of TCCN from tumor margin FOV (C) and derivation of TCCN based on HLA-I status of the iTC (D). Color legend for C and D: tumor (red), macrophage (teal), B cells (orange), Th cells (green), cytotoxic T cells (pink), regulatory T cells (white), neutrophils (purple). In D, HLA-I expression is indicated in yellow. Figure created with Biorender.com.