Table 2.

Univariate Analysis

Variable, Strata Range	Hospital-Associated CDI
	No. of CDI	No. of Admissions	CDI per 10,000 Admissions	P Value
High-risk antibiotic use, day of therapy per 1,000 days present
1st quartile (77–193)	2,902	909,380	31.9	Reference
2nd quartile (194–241)	2,851	837,128	34.1	.0135
3rd quartile (242–295)	2,523	671,853	37.6	<.0001
4th quartile (296–440)	2,029	561,172	36.2	<.0001
Proportion of patients age >65, %
1st quartile (0.14–0.33)	3,080	1,044,253	29.5	Reference
2nd quartile (0.34–0.38)	1,685	556,608	30.3	.3899
3rd quartile (0.39–0.44)	2,823	820,241	34.4	<.0001
4th quartile (0.45–0.65)	2,717	558,431	48.7	<.0001
Community-onset non-hospital-associated (CO-NHA) CDI per 10,000 admissions
1st quartile (3–35)	2,180	965,859	22.6	Reference
2nd quartile (36–56)	2,700	733,345	36.8	<.0001
3rd quartile (57–89)	2,374	644,295	36.8	<.0001
4th quartile (90–273)	3,051	636,034	48.0	<.0001
Average length of stay, days
1st quartile (2.3–3.4)	1,433	524,973	27.3	Reference
2nd quartile (3.5–3.9)	2,213	680,684	32.5	<.0001
3rd quartile (4.0–4.4)	2,898	814,563	35.6	<.0001
4th quartile (4.5–6.0)	3,761	959,313	39.2	<.0001
Proton pump inhibitor use, days of therapy per 1,000 days present
1st quartile (107–265)	2,224	756,480	29.4	Reference
2nd quartile (266–335)	2,610	857,357	30.4	.2262
3rd quartile (336–372)	2,545	641,402	39.7	<.0001
4th quartile (372–701)	2,926	724,294	40.4	<.0001
Hospital teaching status
Nonteaching (n=105)	4,719	1,436,414	32.9	Reference
Teaching (n=66)	5,586	1,543,119	36.2	<.0001
Hospital geographic region
West (n=19)	915	289,972	31.6	Reference
Northeast (n=26)	1,791	418,282	42.8	<.0001
Midwest (n=48)	2,803	808,738	34.7	0.0135
South (n=78)	4,796	1,462,541	32.8	0.2846

Note. CDI, Clostridioides difficile infection.