Table 2.
The logistic regression analyses between possible predictors and cognitive impairment.
| Univariable analysis | Multivariable analysis1 | |||
|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Age | 1.074 (1.034-1.116) | < 0.001 | 1.067 (1.021-1.115) | 0.004 |
| Education | 0.944 (0.894-0.998) | 0.041 | 0.927 (0.871-0.988) | 0.019 |
| SBP | 1.013 (1.000-1.026) | 0.046 | 1.008 (0.993-1.023) | 0.304 |
| HbA1c | 1.417 (1.188-1.690) | < 0.001 | 1.258 (1.028-1.540) | 0.026 |
| History of stroke | 2.330 (1.468-3.696) | < 0.001 | 1.683 (0.977-2.899) | 0.061 |
| HDL | 0.307 (0.125-0.749) | 0.010 | 0.421 (0.143-1.235) | 0.115 |
| Serum tHcy | 1.243 (0.850-1.817) | 0.024 | 1.023 (0.994-1.052) | 0.127 |
| Severe CSVD burden | 3.334 (2.089-5.319) | < 0.001 | 2.198 (1.283-3.763) | 0.004 |
| Medication | ||||
| Insulin Metformin |
1.655 (1.037-2.641) 0.542 (0.317-0.924) |
0.034 0.025 |
1.458 (0.840-2.531) 0.630 (0.337-1.176) |
0.180 0.147 |
| TyG index | 2.811 (1.899-4.160) | < 0.001 | 2.241 (1.439-3.490) | < 0.001 |
SBP, systolic blood pressure; HDL, high density lipoprotein; tHcy, total homocysteine; CSVD, cerebral small vessel disease; TyG, triglyceride glucose.
1Adjusted with P < 0.10 in the Table 1 (age, education, SBP, HbA1c, history of stroke, HDL, serum tHcy, severe CSVD burden, insulin or metformin usage, and TyG index).