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. 2022 Aug 19;17(8):e0273385. doi: 10.1371/journal.pone.0273385

Fig 2. Responses of plasma albumin concentration to Losartan and Ang-(3–4) in normonourished and undernourished rats.

Fig 2

(A) Responses to Losartan. Comparison of plasma albumin concentration in CTRL and RBD rats without chronic administration of Losartan, and effects of Losartan administration (30 mg/kg body mass per day, from 28 to 92 days of life) to CTRL and RBD rats, as indicated on the abscissa. (B) Responses to Ang-(3–4). Effects of oral administration of a single dose of Ang-(3–4) (80 mg/kg body mass), at 91st day of life, to CTRL and RBD rats, as indicated on the abscissa. (C) Responses to Losartan+Ang-(3–4). Effects of combined administration of Losartan and Ang-(3–4) to CTRL and RBD rats, at the doses above indicated, as shown on the abscissa. Samples were collected at 91 days, except for Ang-(3–4)-treated rats, which were collected at 92 days. Bars indicate mean ± SEM; n = 24 (CTRL), n = 28 (RBD), n = 10 (CTRL+Los), n = 21 (RBD+Los), n = 16 (CTRL+Ang-(3–4)), n = 13 (RBD+Ang-(3–4)), n = 17 (CTRL+Los+Ang-(3–4)), n = 19 (RBD+Los+Ang-(3–4)). Differences were assessed using one-way ANOVA followed by Bonferroni’s test for selected pairs. P values are given within the panels.