Table 2. Clinical characteristics of the patients with chronic spontaneous urticaria (CSU) according to the results of serum autoantibodies to FcεRIα.
| Variables (n = 86) | IgG to FcεRIα | IgA to FcεRIα | IgM to FcεRIα | |||
|---|---|---|---|---|---|---|
| Negative | Positive | Negative | Positive | Negative | Positive | |
| (n = 79, 91.8%) | (n = 7, 8.1%) | (n = 81, 94.1%) | (n = 5, 5.8%) | (n = 83, 96.5%) | (n = 3, 3.4%) | |
| Female, n (%) | 50 (63.3%) | 3 (42.9%) | 49 (60.5%) | 4 (80.0%) | 51 (61.4%) | 2 (66.7%) |
| Age (years) | 37.0 [25.0;48.5] | 44.0 [38.0;47.0] | 38.0 [27.0;48.0] | 22.0 [22.0;42.0] | 38.0 [25.0;48.0] | 47.0 [41.0;51.5] |
| Angioedema, n (%) | 38 (48.1%) | 3 (42.9%) | 39 (48.1%) | 2 (40.0%) | 40 (48.2%) | 1 (33.3%) |
| UAS-15 | 10.0 [6.0;13.0] | 7.0 [5.5;11.5] | 10.0 [6.0;13.0] | 9.0 [2.0;12.0] | 10.0 [6.0;13.0] | 15.0 [9.0;15.0] |
| Duration (months) | 10.0 [2.5;27.0] | 7.0 [4.5;8.0] | 8.0 [2.5;24.0] | 10.0 [3.0;12.0] | 9.0 [3.0;24.0] | 1.0 [0.6;3.0] |
| ASST positive, n (%) | 17 (21.5%) | 3 (42.9%) | 19 (23.5%) | 1 (20.0%) | 20 (24.1%) | 0 (0.0%) |
| ANA positive, n (%) | 13 (16.5%) | 3 (42.9%) | 15 (18.5%) | 1 (20.0%) | 15 (18.1%) | 1 (33.3%) |
| Serum total IgE (kU/L) | 132.0 [59.5;288.0] | 396.0 [179.5;538.0] | 139.0 [61.0;294.0] | 182.0 [93.0;520.0] | 143.0 [65.5;312.5] | 68.0 [37.0;296.5] |
| Serum free IgE (ng/mL) | 254.8 [100.7;555.3] | 788.1 [129.1;797.8] | 254.8 [99.3;611.8] | 311.4 [250.9;781.1] | 266.7 [100.7;639.8] | 163.2 [83.3;478.3] |
| Atopy, n (%) | 46 (58.2%) | 7 (100.0%) | 48 (59.3%) | 5 (100.0%) | 52 (62.7%) | 1 (33.3%) |
| Der p IgE (kU/L) | 0.1 [0.1;1.8] * | 18.1 [1.1;24.9] * | 0.2 [0.1;2.4] | 0.5 [0.2;2.0] | 0.2 [0.1;2.0] | 0.2 [0.1;3.4] |
| Der f IgE (kU/L) | 0.3 [0.1;2.5] * | 33.9 [1.3;45.7] * | 0.4 [0.1;4.3] | 1.4 [0.2;1.8] | 0.4 [0.1;3.9] | 0.2 [0.2;3.0] |
| Eosinophil counts (cells/μL) | 93.5 [57.6;161.8] | 62.4 [44.9;155.1] | 93.5 [57.6;162.8] | 65.0 [36.0;156.0] | 93.5 [55.2;168.9] | 70.4 [35.2;96.0] |
| Basophil counts (cells/μL) | 32.0 [22.8;43.0] | 39.0 [33.1;54.8] | 32.4 [22.8;44.0] | 39.6 [32.5;42.7] | 33.0 [23.7;43.6] | 22.8 [14.6;47.4] |
Non-parametric values are shown as median [IQR] and categorical values are shown as number (percentage).
P values were evaluated by Pearson’s Chi-squared test or the Mann-Whitney test.
*P<0.05, between patients with negative results and those with positive results to IgG to FcεRIα.
UAS, urticaria activity score; ASST, autologous serum skin test; ANA, antinuclear antibody; Der p, Dermatophagoides pteronyssinus; Der f, Dermatophagoides farinae