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. 2022 Aug 19;8(33):eabo4363. doi: 10.1126/sciadv.abo4363

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Fig. 1. — (A) The structure of compound Z583. (B) Inhibitory activity and selectivity of Z583 for JAK family kinases at K_m ATP and 1 mM ATP concentration. (C) The IC₅₀ of Z583 and ritlecitinib inhibiting JAK3 at 1 mM ATP concentration. (D) KINOMEscan kinase selectivity profile for Z583 at a concentration of 0.1 μM. (E) The selective inhibition of Z583 against a panel of 48 kinases. (F) The inhibitory potent and selectivity of Z583 for JAK family kinases and kinases with cysteine residue.