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. 2022 Aug 19;8(33):eabo4363. doi: 10.1126/sciadv.abo4363

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Fig. 2. — (A) Z583 can bind to Cys⁹⁰⁹ of the x-ray crystal of JAK3 (PDB ID: 4Z16). (B) Z583 irreversibly inhibits the expression of p-STAT5 after stimulation by γc cytokines of IL-2 or IL-15 in CD4⁺ T cells from C57BL/6, even after being washed extensively with phosphate-buffered saline. (C) LC-MS/MS experiments identified a single modified peptide LVMEYLPSGC*LR (C*, cysteine residue) by Z583 at Cys⁹⁰⁹ position. m/z, mass/charge ratio.