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. Author manuscript; available in PMC: 2022 Aug 19.
Published in final edited form as: Cell Rep. 2022 Jun 28;39(13):111018. doi: 10.1016/j.celrep.2022.111018

Figure 5. Flattening of glucocorticoid oscillations causes hyperinsulinemia within 3 days.

Figure 5.

(A) Blood plasma insulin levels of 6 placebo and 6 cort-pellet-implanted mice (not fasted).

(B) Blood glucose levels of 9 placebo and 9 cort-pellet-implanted mice (not fasted) 14 days after pellet implantation.

(C) Glucose tolerance test (GTT) after 21 days of treatment of 5 placebo and 5 cort-pellet-implanted mice.

(D) Insulin tolerance test (ITT) after 17 days of treatment of 5 placebo and 6 cort-pellet-implanted mice. (A–D) Means ± SEMs, unpaired t test; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

(E) GTT of 6 placebo and 6 cort-injected mice after 21 days of treatment; means ± SEMs.

(F) ITT of 5 placebo and 6 cort-injected mice after 17 days of treatment; means ± SEMs.