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. Author manuscript; available in PMC: 2022 Aug 19.
Published in final edited form as: Cell Rep. 2022 Jun 28;39(13):111018. doi: 10.1016/j.celrep.2022.111018

Figure 6. The hyperinsulinemia and much of the adipocyte hypertrophy are reversible when the glucocorticoid flattening stimulus is removed.

Figure 6.

(A) Time course of insulin levels in blood plasma in 6 placebo and 6 cort-pellet-implanted mice (not fasted); means ± SEMs; unpaired t test; *p < 0.05, **p < 0.01.

(B) Fat pad weight measured 21 and 42 days after pellet implantation, n = 5–9, means ± SDs. Unpaired t test; **p < 0.01, ****p < 0.0001. Data from 21 days is the same as in Figures 1E and 1F, second panel.

(C) Schematic representation of the commonly discussed acute and chronic stress states, as well as a reversible intermediate state arising from 3 weeks of glucocorticoid flattening. Mice can mostly recover from this intermediate alert state without long-term adipocyte dysfunction. See also Figure S6.