Table 4.
Performance metrics for the diagnosis of children with TB, for the three cohorts and for the pooled datasets
| Cohort | Performance metric | Confirmed TB | Unconfirmed TB | Unlikely TB with any criteria | No NIH criteria and non-TB control |
|---|---|---|---|---|---|
| NLH (20 children) | Fraction of children | 14/15 | – | – | 0/5 |
| Sensitivity, % | 93.3 (68.1, 99.8) | – | – | – | |
| Specificity, % | – | – | – | 100.0 (47.8, 100.0) | |
| DR (43 children) | Fraction of children | 15/17 | 9/11 | 1/3 | 1/12 |
| Sensitivity, % | 88.2 (63.6, 98.5) | 81.8 (48.2, 97.7) | 33.3 (0.8, 90.6) | – | |
| Specificity, % | – | – | 66.7 (9.4, 99.2) | 91.7 (61.5, 99.8) | |
| PUSH (147 children) | Fraction of children | 10/12 | 48/66 | 31/57 | 2/12 |
| Sensitivity, % | 83.3 (51.6, 97.9) | 72.7 (60.4, 83.0) | 54.4 (40.7, 67.6) | – | |
| Specificity, % | – | – | 45.6 (32.4, 59.3) | 83.3 (51.6, 97.9) | |
| Pooled (210 children) | Fraction of children | 39/44 | 57/77 | 32/60 | 3/29 |
| Sensitivity, % | 88.6 (75.4, 96.2) | 74.0 (62.8, 83.4) | 53.3 (40.0, 66.3) | – | |
| Specificity, % | – | – | 46.7 (33.7, 60.0) | 89.7 (72.6, 97.8) |
The fraction of children refers to the fractions that were positive according to Mtb EV. Confidence intervals (95%) for the sensitivities and specificities are given in brackets.