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. 2022 Apr 26;18(6):2059–2073. doi: 10.1007/s12015-022-10378-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — In vitro and in vivo, ADMSC-Exos affects the synthesis of collagen and α-SMA in fibroblasts. A The qPCR analysis of the mRNA expression of COL-I, COL-III, α-SMA in human fibroblasts treated with different concentrations of ADMSC-Exos. B, C Western blotting of the protein expression level of COL-I, COL-III, α-SMA in fibroblasts treated with different concentrations of ADMSC-Exos. D, E, F Representative images of immunohistochemistry showed COL-I, COL-III, α-SMA expression in the designated treatment group. The data were statistically analyzed using GraphPad. Results are presented as mean ± SD; n = 3; ^*p < 0.05, compared with 0 μg/ml group. Scale bars, 100 μm (10x), 50 μm (20x)