Table 4.
Association between vitamin E–related gene SNPs and prostate cancer risk among 8,383 Finnish male smokers in the ATBC Study
| SNP | Gene | Chromosome | Minor allele | MAF | Number of participants | Prostate cancer diagnosis (%) | OR (95%CI)a | Mean serum α-tocopherol (mg/L) by genotype | Ptrendb |
|---|---|---|---|---|---|---|---|---|---|
| rs964184 | BUD13/ZNF259/APOA5 | 11 | G | 0.15 | |||||
| CC | 6 096 | 26.4 | 1.00 (Ref) | 11.8 | 0.09 | ||||
| GC | 2 115 | 24.1 | 0.90 (0.80 1.01) | 12.6 | |||||
| GG | 172 | 26.7 | 1.02 (0.72, 1.44) | 13.6 | |||||
| rs2108622 | CYP4F2 | 19 | T | 0.19 | 0.50 | ||||
| CC | 5 505 | 26.0 | 1.00 (Ref) | 11.9 | |||||
| TC | 2 590 | 25.8 | 1.00 (0.89, 1.11) | 12.2 | |||||
| TT | 288 | 23.6 | 0.89 (0.67, 1.17) | 12.9 | |||||
| rs11057830 | SCARB1 | 12 | A | 0.13 | 0.08 | ||||
| GG | 6 314 | 25.5 | 1.00 (Ref) | 11.9 | |||||
| AG | 1 919 | 26.8 | 1.08 (0.96, 1.21) | 12.3 | |||||
| AA | 150 | 31.3 | 1.35 (0.95, 1.92) | 12.7 |
Models adjusted for age at randomization, body mass index, years of cigarette smoking, number of cigarettes smoked daily, serum total cholesterol concentration, and trial intervention group.
Two-sided Ptrend is based on the statistical significance of the coefficient for the allele variable of each SNP
Abbreviations: MAF, minor allele frequency; OR, odds ratio; 95%CI, 95 % confidence interval; Ref, referent; BUD13, budding-site selection protein 13 (yeast); ZNF259, zinc finger protein 259; APOA5, apolipoprotein A5; CYP4F2, cytochrome p450, family 4, subfamily F, polypeptide 2; SCARB1, scavenger receptor class-B member 1; ATBC, Alpha-Tocopherol, Beta-Carotene Cancer Prevention, SNP, single-nucleotide polymorphisms.