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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: J Hepatol. 2022 Apr 12;77(3):723–734. doi: 10.1016/j.jhep.2022.03.029

Fig. 7. Endothelial cell-specific inhibition of glycolysis attenuates neutrophil infiltration and development of portal hypertension in vivo.

Fig. 7.

A. Portal pressure measurement shows attenuated portal hypertension in HK2 fl/fl Cdh5 Cre-ERT2 mice (=endothelial cell specific HK2 knockdown) after pIVCL compared with HK2 fl/fl mice (n=3-9, *p<0.05). B. CXCL1 mRNA expression is significantly increased after pIVCL in HK2 fl/fl, while this increase is attenuated in HK2 fl/fl Cdh5 Cre-ERT2 mice (n=5-11, *p<0.05, **p<0.01). C. MPO mRNA expression is significantly increased after pIVCL in HK2 fl/fl, while this increase is attenuated in HK2 fl/fl Cdh5 Cre-ERT2 mice (n=5-11, *p<0.05). D. Immunohistochemistry for MPO shows attenuated neutrophil infiltration in HK2 fl/fl Cdh5 Cre-ERT2 mice after pIVCL compared with HK2 fl/fl mice (n=7-14, ***p<0.001). Left panel shows representative pictures (arrowheads indicate neutrophils), right panel shows quantification.