Figure 2: Clinical diagnoses of participants at the evaluation closest to autopsy by pathology.

The distributions of clinical diagnoses at the clinical evaluation closest to death presented in the participants divided by each of the four pathologic factors (A-D) suggests while there was no significant difference between individuals with PART vs ADNC and between those with vs without vascular pathology, individuals with higher Braak stages or concomitant LATE-NC were more likely to be demented prior to death. Since concomitant LATE-NC pathology is more likely among those with higher Braak stages (Figure 1C), we examined the interaction of those pathologies with regards to the diagnosis (D) and observed that either higher Braak stages, concomitant LATE-NC, or both appear to increase the likelihood of a dementia diagnosis compared to those with neither pathology. If the number of significant pathologic factors (tallied across higher Braak, concomitant LATE-NC, and concomitant Vascular) are examined by the final clinical diagnosis (F), we can see that those with dementia were far more likely (>75%) to have at least one of these pathologies compared to those with either MCI or Normal cognition (<50%).