Figure 3: Cognitive performance at the evaluation closest to autopsy by pathologic factor.

Cognitive performance of the participants at the evaluation closest to death is presented as a function of higher Braak stage (A), concomitant LATE-NC pathology (B), or concomitant vascular pathology (C) divided by group (i.e. PART vs ADNC). There were no significant differences in performance between PART and ADNC on any measures, and no significant interactions of the group term with each of the three other pathologic factors, suggesting that they produce similar effects on cognition across the groups. However, those with higher Braak stages performed worse on each of the three global cognitive measures (MMSE, DRS, CDR-sob), as well as the Memory cognitive composite. Similarly, those with concomitant LATE-NC pathology performed worse on the three global measures and both the Memory and Language composites. Those with concomitant vascular pathology declined more rapidly on the DRS. For effect sizes and p value please see Table 4.