Table 1:
Participant Characteristics
| PART (N=44) | ADNC (N=52) | P value | |
|---|---|---|---|
| Age at Death (y) | 88.0 ± 7.4 | 89.1 ± 6.2 | 0.44 |
| Age at Final Visit | 86.7 ± 7.3 | 88.4 ± 6.4 | 0.24 |
| Final Visit – Autopsy Interval | 1.2 ± 1.4 | 0.9 ± 1.1 | 0.27 |
| Female | 19 (43%) | 24 (46%) | 0.93 |
| Thal Phase: 0 (A0) / 1–2 (A1) / 3 (A2) / 4–5 (A3) |
20 / 24 / 0 / 0 (45% / 55% / 0% / 0%) |
0 / 0 / 13 / 39 (0% / 0% / 25% / 75%) |
(definition) |
| Braak Stage: I-II (B1) / III-IV (B2) / V-VI (B3) |
29 / 15 / 0 (66% / 34% / 0%) |
34 / 18 / 0 (65% / 35% / 0%) |
0.99 |
| Neuritic Plaques: None (C0) / Sparse (C1) / Moderate (C2) / Frequent (C3) |
39 / 5 / 0 / 0 (89% / 11% / 0% / 0%) |
0 / 9 / 38 / 5 (0% / 17% / 73% / 10%) |
6.79 × 10 −18 |
| LATE-NC: None / Amyg / Limbic / Neocortical |
34 / 3/ 7/ 0 (77% / 7% / 16% / 0%) |
40 / 4 / 5 / 3 (77%, 8% / 10% / 6%) |
0.35 |
| Amyloid Angiopathy: None / Mild / Moderate / Severe |
31 / 7 / 5 / 1 (70% / 16% / 11% / 2%) |
18 / 13 / 13 / 8 (35% / 25% / 25% / 15%) |
0.004 |
| Atherosclerosis: None / Mild / Moderate / Severe |
8 / 15 / 14 / 6 (18% / 34% / 32% / 14%) |
7 /12 / 26 / 7 (13% / 23% / 50% / 13%) |
0.35 |
| Arteriolosclerosis: None / Mild / Moderate / Severe |
12 / 13 / 16 / 3 (27% / 30% / 36% / 7%) |
16 / 18 / 16 / 2 (31% / 35% / 31% / 4%) |
0.82 |
| Infarcts | 8 (18%) | 12 (23%) | 0.74 |
| Microinfarcts | 4 (9%) | 10 (19%) | 0.27 |
| Hemorrhage/Microbleeds | 2 (5%) | 3 (6%) | 0.99 |
| Hippocampal Sclerosis | 7 (16%) | 10 (19%) | 0.88 |