Table 4:
Statistics for longitudinal slopes of decline by pathologic feature and their interaction with group
| PART vs ADNC | Braak I-II vs Braak III-IV | LATE-NC− vs LATE-NC + | Vasc− vs Vasc+ | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Coefficient (95% CI) | Group P value | Coefficient (95% CI) | Braak P value | Group Interaction P value | Coefficient (95% CI) | LATE P value | Group Interaction P value | Coefficient (95% CI) | Vasc P value | Group Interaction P value | |
| MMSE | −0.16 (−1.11 – 0.79) | 0.752 | −1.31 (−2.40 – −0.32) | 0.019 | 0.289 | −1.89 (−3.04 – −0.84) | 0.002 | 0.706 | −0.34 (−1.52 – 0.74) | 0.562 | 0.309 |
| DRS | 0.12 (−3.77 – 4.08) | 0.952 | −4.07 (−8.42 – −0.06) | 0.066 | 0.258 | −7.76 (−12.74 – −3.36) | 0.002 | 0.546 | −5.18 (−10.18 – −0.63) | 0.037 | 0.194 |
| CDR-sob | 0.61 (−0.81 – 2.08) | 0.439 | 2.77 (1.47 – 4.18) | <0.001 | 0.417 | 1.93 (0.38 – 3.66) | 0.029 | 0.202 | 0.55 (−0.75 – 1.91) | 0.455 | 0.838 |
| Memory | 0.14 (−0.14 – 0.43) | 0.351 | −0.4 (−0.72 – −0.10) | 0.015 | 0.409 | 0.03 (−0.31 – 0.35) | 0.864 | 0.375 | −0.01 (−0.37 – 0.36) | 0.951 | 0.555 |
| Executive | 0.15 (−0.25 – 0.56) | 0.471 | 0.00 (−0.44 – 0.45) | 0.998 | 0.619 | −0.06 (−0.55 – 0.44) | 0.829 | 0.769 | −0.40 (−0.92 – 0.13) | 0.151 | 0.829 |
| Visuospatial | −0.02 (−0.49 – 0.46) | 0.952 | −0.01 (−0.53 – 0.50) | 0.977 | 0.529 | −0.19 (−0.78 – 0.39) | 0.540 | 0.935 | 0.00 (−0.61 – 0.59) | 0.990 | 0.066 |
| Language | −0.21 (−0.52 – 0.09) | 0.194 | −0.12 (−0.46 – 0.22) | 0.517 | 0.539 | −0.48 (−0.84 – −0.13) | 0.013 | 0.757 | 0.02 (−0.39 – 0.41) | 0.921 | 0.742 |
For each cognitive test or composite, the coefficient (99% Confidence Interval) for the annualized rate of decline is provided along with the p value for each pathologic term as indicated along the top. For each pathologic term other than the Group term (i.e., PART vs ADNC), the p value for the interaction of the pathologic term with Group is also provided so assess if the effects differ between those with PART or ADNC.