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. 2022 Aug 19;13:4880. doi: 10.1038/s41467-022-32613-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic representation of Uba6~Ub thioester formation reaction. b Cartoon representation of crystal structure of Uba6/Ub-AMP/InsP6 in the open E1 conformation. IAD domain is in slate; AAD is in pink; FCCH is in hotpink; SCCH is in magenta; UFD is in orange; cys cap is in cyan; and Ub(a) is in gold. The catalytic cysteine is indicated by yellow sphere. AMP and InsP6 are indicated by spheres. c Cartoon representation of crystal structure of hUba6/Ub-AMP in the closed E1 conformation presented as in b. Schematic drawings of the domain organization of Uba6 with disordered regions indicated by hatched boxes are shown at the bottom of b and c.