Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 19;5:846. doi: 10.1038/s42003-022-03800-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a Experimental timeline and tissue collection schedule (black bars represent darkness, white bars indicate periods of light). b Percentage of wakefulness during the first half (ZT0-6) and the second half (ZT6-12) of sleep deprivation. c, d Ribbon plots showing the time course of 2 hourly binned values of (c) NREM state and (d) NREM delta (δ)-power percentage of ZT8-12 from Day 1. Horizontal red bar represents the timeline of sleep deprivation (Day 2, ZT 0-12; 12 h duration). Pink and blue bars under the plots denote significant increase and decrease, respectively, compared to Day 1 (P < 0.05). Data are mean ± s.e.m. n = 6 biological replicates. Paired t-test, two-tailed (b). Repeated-measures two-way ANOVA followed by post-hoc Fisher’s Least Significant Difference (LSD) test (c and d). For sample sizes and statistics, see Supplementary Data 1.