Figure 6.

Secondary electrophysiological changes sufficiently recapitulate E4031 treatment arrhythmogenesis

(A) Total count of all parameters that scored >20 on the feature importance metrics across XGB models trained with reduced input variables. Top: repolarization 30% and 60% durations excluded. Bottom: all repolarization duration features excluded.

(B) Performance metrices of the XGB binary classifiers from the 60:40 train-test split compared with models trained with reduced input variables. Left: accuracy. Middle: sensitivity. Right: specificity. Mean ± SD is plotted (n = 100 independent bootstraps).