Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 19;12:14158. doi: 10.1038/s41598-022-17913-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Schematic representation of RUNX1/ETO tetramerization. (A) Depiction of the chimeric RUNX1/ETO fusion protein containing the nucleotide-binding domain (NBD) and four nervy homology regions (NHR). The NHR2 domain (marked in blue) mediates homo-tetramerization. (B) X-ray crystal structure (PDB ID 1WQ6) of the NHR2 domain. For the clarity of the tetrameric α-helical bundle, one antiparallel α helical pair is shown in ribbon view and the other in surface view. The five predicted hot spot residue¹¹ side chains (W498, W502, D533, E536, and W540) are shown in stick representation and colored by elements (C) Primary amino acid sequence of the NHR2 domain shown in black, hot spot residues are colored in red, other ETO residues in gray. (D) Molecular structure of 7.44.