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. 2022 Aug 19;12:14158. doi: 10.1038/s41598-022-17913-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cytochrome P450 (CYP) inhibition assay for 7.44. The inhibition assays were performed for seven CYP enzymes at two different concentrations, 1 µM (blue) and 10 µM (green). 7.44 showed a potential to inhibit CYP2B6, 2C9, 2C19, and 3A4. For the other tested enzymes, CYP1A2, 2C8, and 2D6, the potential is regarded low (with estimated IC₅₀ values > 10 µM).