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. 2022 Aug 19;12:14162. doi: 10.1038/s41598-022-18422-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Protein–protein interaction (PPI) networks of DEGs. The PPI information of DEGs potentially involved in transcription and translation and chromatin organization (a), and metabolism (b), was obtained through a database search using STRING database v11 with a high confidence score (0.9), and imported into Cytoscape v3.8.2 (https://cytoscape.org/) for network construction and plotting. Proteins and their interactions are shown as nodes (spheres) and edges (lines), respectively. Nodes in red or green color indicate upregulated and downregulated DEGs, respectively. Proteins are grouped based on their known biological functions. OXPHOS, oxidative phosphorylation; PPP, pentose phosphate pathway; TCA, tricarboxylic acid.