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. 2022 Aug 19;12:14182. doi: 10.1038/s41598-022-17987-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CB1 receptors regulate basal salivation. In male (A) and female (C) mice, THC (mg/kg, IP) or CP55940 (0.5 mg/kg) reduced basal salivation 1 h after treatment. The CB1 antagonist SR141716 (4 mg/kg) had no effect. (B,D) THC had no effect in CB1 knockout males (B) or females (D). (E) CBD (4 mg/kg) had no effect on salivation in males or females. (F) CBD reversed the effects of THC in a concentration-dependent manner. (G) Effect of CP55940 persists for at least six hours. **p < 0.01; ***p < 0.005, one-way ANOVA with Dunnett’s post-hoc test vs. control.