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. 2022 Aug 19;12:14182. doi: 10.1038/s41598-022-17987-2

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© The Author(s) 2022

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CB1 signaling system in submandibular gland. Schematic of submandibular gland showing acinar and ductal epithelial cells as well as enveloping myoepithelial cells (violet). CB1 receptors (red) are seen on the axons of parasympathetic neurons originating in the submandibular ganglion. FAAH, restricted to acinar cells, metabolizes acylethanolamines, including anandamide. NAPE-PLD likely resides in myoepithelial cells.