Figure 1.

Schematic of a healing wound

A schematic of a healing wound. Epithelial cells migrate down between scab (brown) and healthy granulation tissue (yellow) to seal the wound gap. Cut epithelial appendages (eg hair stumps) can contribute to this wound re-epithelialization. Inflammatory cells (dark blue) are drawn to the wound by chemoattractants released from wound edge cells and other “damage” signals. Inflammatory cells roll along the activated luminal surface and then extravasate from vessels adjacent to the wound (left inset), and then orchestrate the activities of many cell lineages at the wound, including the sprouting wound angiogenesis of endothelial cells and the laying down of collagen fibrils by fibroblasts (pale blue) to make wound scar (right inset).