Figure 4.

Modeling of the wound inflammatory response in the Drosophila pupal wing

(A) Still image from a movie of a wound (white dashed line) made to the Drosophila pupal wing. Macrophages (green cytoplasm with red stingerRFP nuclei) are attracted to the wound by, as yet, unknown damage signals. a’ – tracks in a.

(B) A diffusion equation with a fixed time period models the source and movement of the signal. Parameters of the equation can be estimated using Bayesian inference. a-concentration of attractant, D – diffusion coefficient, $\text{τ}$ – signal production time.

(C-C’ and D-D’) A simulation of wound chemoattractant using the parameters after 10mins and 30mins whereby warmer colors indicate a higher concentration (adapted with permission from Weavers et al., 2016).