Table 2.
Gene ontology (GO) analysis of differentially expressed genes (DEGs) for overrepresentation
| Cluster | GO terms - upregulated DEGS in aged | FDR | GO terms - downregulated DEGS in aged | FDR |
|---|---|---|---|---|
| CL-R | Immune system | 8.51E-07 | Ubiquitin proteasome pathway | 3.01E-07 |
| Regulation of IGF transport and uptake by IGFBPs | 4.77E-04 | Integrin signaling pathway | 1.96E-05 | |
| Extracellular matrix organization | 1.63E-03 | Cell cycle | 5.47E-03 | |
| Stroma | Respiratory electron transport | 2.24E-14 | Eukaryotic translation initiation | 1.59E-44 |
| Innate Immune System | 6.13E-03 | Mitochondrial biogenesis | 1.79E-09 | |
| ER to Golgi Anterograde Transport | 1.23E-02 | Formation of annular gap junctions | 5.74E-05 | |
| Follicle | Regulation of gap junction activity | 9.40E-03 | Translation | 5.48E-60 |
| Antagonism of activin by follistatin | 1.17E-02 | ER quality control compartment | 1.17E-02 | |
| Signaling by TGF-beta family members | 2.04E-02 | Organelle biogenesis and maintenance | 1.48E-02 | |
| CL-P | Pink/Parkin Mediated Mitophagy | 1.29E-03 | Translation | 6.43E-58 |
| Mitophagy | 3.55E-04 | Eukaryotic translation initiation | 1.05E-50 | |
| Detoxification of Reactive Oxygen Species | 3.83E-03 | Mitochondrion translation | 3.43E-05 | |
| Epithelium1 | N/Aa | N/Aa | Mitotic cell cycle | 3.10E-06 |
| Calnexin/calreticulin cycle | 6.34E-06 | |||
| Collagen formation | 4.07E-02 | |||
| Epithelium2 | Keratan sulfate degradation | 1.01E-02 | N/Sb | N/Sb |
| Epithelium3 | N/Aa | N/Aa | Mitochondrial biogenesis | 2.36E-07 |
| Collagen biosynthesis and modifying enzymes | 8.33E-03 | |||
| Collagen formation | 2.95E-02 |
CL-R, Corpus Luteum-Regressing; CL-P, Corpus Luteum-Progressing.
a
Not enough upregulated DEGs for analysis.
b
No significant results.