Figure 8.

Schisandrin A directly targeted AdipoR1 protein. (a) The 3D image revealed that Schisandrin A bond to the binding pocket and formed with AdipoR1. (b) Microscale thermophoresis (MST) of Schisandrin A and AdipoR1 incubated with Schisandrin A. (c) TSA results in the presence or absence of Schisandrin A. (d) The thermal stability of WT AdipoR1 and Mut AdipoR1 plasmid after treatment with Schisandrin A using CETSA. (e) CETSA curve and the thermal stability to reach 50% of temperature (Tm50) value.