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. 2022 Aug 11;2022:5411462. doi: 10.1155/2022/5411462

Figure 9.

Figure 9

The regulation of AdipoR1 affected the effects of Schisandrin A in mice model of DN. (a and b) AdipoR1, p-AMPK, Nrf2, HO-1, and SOD2 protein expression in mice model; (c) glomerulus injury (Masson staining); (d) blood glucose; (e) body weight; (f) kidney/body weight; (g) serum creatinine; (h) urea nitrogen; (i) urinary albumin levels; (j) water intake (24 h); (k) E-cadherin mRNA expression; and (l) periostin mRNA expression in mice of DN. Control, sham control mice group; model, STZ-induced mice DN group; low/med/high, mice DN by treatment with 25/50/100 mg/kg of Schisandrin A group; Poly, 50 mg/kg of Schisandrin A group; AdipoR1 i, sh-AdipoR1 group; AdipoR1, AdipoR1 Agonist group; ##P < 0.01 versus control group; ∗∗P < 0.01 versus STZ-induced mice DN group; ∗∗∗P < 0.01 versus 50 mg/kg of Schisandrin A group; ###P < 0.01 versus 50 mg/kg of Schisandrin A group.