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. 2022 Aug 20;12:14210. doi: 10.1038/s41598-022-18244-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Viral load and inflammation trajectory characteristics by inflammation trajectory groups. (a) Viral loads over the course of infection. The shaded area corresponds to the 10th and 90th percentiles of the viral loads, while the curve represents the median. (b) The distribution of peak viral loads, (c) the VL decay from peak infection to 5 days after peak infection and (d) the time of occurrence of peak VL after infection. (e) Inflammation trajectories by inflammation trajectory groups. The shaded area corresponds to the 10th and 90th percentiles of $D_{1}$ , while the curve represents the median. (f) the distribution of peak $D_{1}$ , (g) the distribution of $D_{1}$ at 60 days post-infection and (h) the time of occurrence of peak $D_{1}$ after infection. In orange and represented by the symbol R, Resolved inflammation. In pink and represented by the symbol H, Hyperinflammation.