TABLE 2.

Difference in Area Under the Receiver Operating Characteristic Curve and 95% Confidence Interval for Comparisons of Classification Protocols

Classification Protocol Comparison	ΔAUC	95% Confidence Interval of the Difference	P Value	Statistical Conclusion
Signature based on feature selection on all features compared to maximum linear size	−0.049	(−0.081 to −0.018)	.005	Superior
Signature based on feature selection on all features excluding size compared to maximum linear size	−0.050	(−0.080 to −0.024)	.003	Superior
Signature based on feature selection on all features excluding size compared to that on all features	−0.002	(−0.013 to 0.008)	.664	Equivalent

AUC, area under the receiver operating characteristic curve.

P values shown are after correction for multiple comparisons.

Statistical conclusion was based upon superiority and equivalence testing.