Table 3.
Univariate and Multivariate Analysis of YAP1/FAPα and Clinical Characteristics for Overall Survival of NPC Patients
| YAP1 | Univariate analysis | Multivariate analysis | ||
| n = 106 | HR (95% CI) | p value | HR (95% CI) | p value |
| YAP1 Score (≥80 vs. < 80) | 1.447 (0.782–2.679) | 0.239 | 2.402 (1.218–4.737) | 0.011 |
| Treatment Daysa | 1.074 (0.999–1.156) | 0.053 | 1.142 (1.049–1.242) | 0.002 |
| BEDa | 0.982 (0.882–1.093) | 0.737 | 0.887 (0.791–0.995) | 0.04 |
| Age Group (≥48 vs. < 48) | 1.086 (0.587–2.009) | 0.792 | 0.632 (0.288–1.389) | 0.253 |
| Gender (Male vs. Female) | 2.412 (1.014–5.738) | 0.046 | 3.657 (1.356–9.862) | 0.01 |
| T-Stage (T3/4 vs. T1/2) | 1.956 (1.034–3.701) | 0.039 | 3.584 (1.579–8.139) | 0.002 |
| N-Stage (N2/3 vs. N0/1) | 1.394 (0.752–2.582) | 0.291 | 1.554 (0.787–3.069) | 0.204 |
| Chemotherapy (Yes vs. No) | 0.901 (0.449–1.911) | 0.77 | 1.180 (0.515–2.706) | 0.696 |
| Comorbidity (Yes vs. No) | 1.923 (1.041–3.551) | 0.037 | 3.277 (1.493–7.190) | 0.003 |
| Smoking (Yes vs. No) | 1.417 (0.756–2.658) | 0.277 | 0.945 (0.453–1.971) | 0.879 |
| Betel quid (Yes vs. No) | 1.707 (0.870–3.348) | 0.12 | 0.980 (0.408–2.355) | 0.964 |
| Alcohol (Yes vs. No) | 1.361 (0.733–2.527) | 0.329 | 1.286 (0.588–2.812) | 0.528 |
| FAPα | Univariate analysis | Multivariate analysis | ||
| n = 143 | HR (95% CI) | p value | HR (95% CI) | p value |
| FAPα Score (≥80 vs. < 80) | 1.248 (0.890–2.259) | 0.463 | 1.009 (0.521–1.953) | 0.979 |
| Treatment Daysa | 1.044 (0.988–1.103) | 0.129 | 1.039 (0.978–1.104) | 0.212 |
| BEDa | 1.007 (0.939–1.081) | 0.837 | 0.965 (0.887–1.049) | 0.403 |
| Age Group (≥48 vs. < 48) | 1.456 (0.804–2.635) | 0.215 | 1.340 (0.691–2.596) | 0.386 |
| Gender (Male vs. Female) | 1.338 (0.681–2.631) | 0.398 | 1.364 (0.623–2.990) | 0.437 |
| T-Stage (T3/4 vs. T1/2) | 2.610 (1.403–4.855) | 0.002 | 3.324 (1.603–6.894) | 0.001 |
| N-Stage (N2/3 vs. N0/1) | 1.313 (0.738–2.338) | 0.354 | 1.257 (0.672–2.351) | 0.474 |
| Chemotherapy (Yes vs. No) | 0.766 (0.401–1.463) | 0.419 | 0.525 (0.243–1.133) | 0.101 |
| Comorbidity (Yes vs. No) | 1.432 (0.797–2.570) | 0.23 | 1.686 (0.872–3.263) | 0.121 |
| Smoking (Yes vs. No) | 1.046 (0.587–1.864) | 0.878 | 0.893 (0.437–1.824) | 0.757 |
| Betel quid (Yes vs. No) | 1.555 (0.831–2.909) | 0.167 | 1.837 (0.867–3.893) | 0.112 |
| Alcohol (Yes vs. No) | 0.978 (0.523–1.831) | 0.946 | 0.716 (0.327–1.568) | 0.404 |
acontinuous variable. BED Biologically effective dose, HR Hazard ratio, CI Confidence interval