Table 2.
Comparison of perioperative outcomes (excluding patients with severe chronic kidney disease)
| Outcomes | SGLT2-i (n = 27) | Matched Controls (n = 95) | p-value |
|---|---|---|---|
| Metabolic acidosis with euglycemia, n (%) | 6 (22.2) | 6 (6.3) | 0.024 |
| Metabolic acidosis, n (%) | 6 (22.2) | 7 (7.4) | 0.038 |
| ICU stay, hours, median [IQR] | 23.00 [21.00, 47.50] | 22.00 [18.00, 54.50] | 0.15 |
| Blood gas analysis of the lowest pH at ICU admission | |||
| Lowest pH, median [IQR] | 7.33 [7.30, 7.36] | 7.35 [7.32, 7.38] | 0.11 |
| PaCO2, mmHg, median [IQR] | 40.20 [36.00, 44.35] | 44.00 [40.05, 46.90] | 0.002 |
| Glucose, mg/dL, median [IQR] | 144.00 [119.50, 171.00] | 164.00 [133.50, 203.00] | 0.027 |
| Lactate, mmol/L, median [IQR] | 1.41 [1.10, 1.81] | 1.31 [1.08, 1.86] | 0.94 |
| Sodium, mEq/L, median [IQR] | 137.20 [135.10, 138.35] | 136.20 [134.45, 137.90] | 0.20 |
| Potassium, mEq/L, median [IQR] | 4.14 [3.76, 4.52] | 4.05 [3.88, 4.24] | 0.31 |
| Chloride, mEq/L, mean (SD) | 106.59 (4.02) | 105.23 (3.29) | 0.074 |
| Bicarbonate, mEq/L, median [IQR] | 22.00 [18.55, 23.20] | 23.70 [22.60, 25.10] | < 0.001 |
| Base excess, mmol/L. median [IQR] | -3.70 [-6.90, -2.05] | -2.20 [-3.45, -0.55] | < 0.001 |
| Anion gap, mEq/L, median [IQR] | 13.30 [11.45, 16.55] | 10.70 [9.10, 12.50] | 0.002 |
Abbreviation: ICU Intensive care unit, IQR Interquartile range, PaCO2 Partial pressure of arterial carbon dioxide, SD Standard deviation. Significant p-values (p < 0.05) are given in bold