Table 3.
Cox regression model estimates of all-cause mortality hazard ratios (HRs) with 95% confidence intervals (CIs)
| Univariable | First model 1 | Second model2 | ||
|---|---|---|---|---|
| HRa (95% CI) | HRa (95% CI) | HRa (95% CI) | ||
| Hospital mCRC case load | 1st quartile | 1 | 1 | 1 |
| 2nd quartile | 0.93 (0.87–0.99) | 1.01 (0.95–1.07) | 1.04 (0.98–1.11) | |
| 3rd quartile | 0.97 (0.92–1.04) | 1.02 (0.96–1.09) | 1.07 (1.00–1.14) | |
| 4th quartile | 0.87 (0.82–0.93) | 0.92 (0.86–0.98) | 1.06 (0.98–1.14) | |
| Hospital level | Non-university | 1 | 1 | 1 |
| University | 0.81 (.78–0.85) | 0.85 (0.81–0.89) | 0.83 (0.78–0.88) | |
Model includes 9,968 patients with synchronous colorectal cancer metastases
aAdjusted for time since diagnosis
1One exposure (hospital volume/ hospital level) and adjusted for sex (male, female), age (categorized: 18–64,65–79, ≥ 80 years), Charlson comorbidity index (0,1, ≥ 2), Primary tumour location (right colon, transverse colon, left colon, colon unknown location in colon, rectum), cT (1–3, 4, X) cN, (0, 1–2, X), metastases (single, multiple), civil status (married, not married), education (primary, secondary, higher education), annual income (quartiles), year of diagnosis. Missing data handled using missing indicator method
2Model of both exposures, adjusted as above