Fig. 3.

Comparison of ZicoSeq to the top-scoring method under different settings for stool and vaginal data. a Balanced and b unbalanced change setting (sample size = 100, taxa number = 500). c Balanced and d unbalanced change setting (sample size = 50, taxa number = 500). e Balanced and (f) unbalanced change setting (sample size = 100, taxa number = 50). Performance is assessed by the observed false discovery rate (FDR) level and average true positive rate (TPR). The color of the bar indicates the FDR control performance. The blue color indicates that the method controls the FDR at the 5% target level (the 95% confidence interval covers 5%). Yellow, red, and gray colors indicate the observed FDR level in (0.05–0.1), (0.1, 0.2), and (0.2, 1), respectively. The length of the bar is proportional to the TPR, and the actual TPR is shown in the bar