. 2022 Aug 19;10:130. doi: 10.1186/s40168-022-01320-0

Table 1.

Configurations of the simulation settings used in the evaluation of differential abundant analysis methods

Setting				Sample size (n)			Taxa number (m)		Depth confounding			Signal density			Differential mode
				50	100	200	50	500	No	Yes (-fold)		Low	Medium	High	Abundant	Rare
				50	100	200	50	500	No	4	9	5%	10%	20%	Abundant	Rare
Binary	Global null		1	✓		✓	✓	✓	✓
	Balanced	Basic setting	2		✓			✓	✓			✓	✓	✓	✓	✓
		Small n	3	✓		✓		✓	✓			✓	✓	✓	✓	✓
		Small m	4		✓		✓		✓			✓	✓	✓	✓	✓
		Depth confounding	5		✓			✓		✓	✓	✓	✓	✓	✓	✓
	Unbalanced	Basic setting	6		✓			✓	✓			✓	✓	✓	✓
		Small n	7	✓				✓	✓			✓	✓	✓	✓
		Small m	8		✓		✓	✓	✓			✓	✓	✓	✓
Binary + confounder	Balanced	Basic setting	9		✓			✓	✓			✓	✓	✓	✓	✓
Binary + confounder	Unbalanced	Basic setting	10		✓			✓	✓			✓	✓	✓	✓