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. 2022 Aug 20;14:172. doi: 10.1007/s40820-022-00922-5

Fig. 1.

Fig. 1

Risk evaluation of nanomedicine devices based on estimation of internal and external exposure. Based on the type of organ, duration of exposure of nanomaterials, and their physicochemical characteristics, humans can be subject to negligible or high internal exposure to nanomaterials. The figure is drawn based on the data provided in the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) report entitled “Guidance on the determination of potential health effects of nanomaterials used in medical devices” [25]