Figure 4: Associations between schizophrenia and cell types from multiple brain regions in human and mouse.

a, b, The mean of the evidence (−log₁₀ P value) obtained from two methods (MAGMA and LDSC) for testing GWAS data for enrichment of associations in genes with high expression in cell types. 15 human cell types (derived from single nuclei) from the cortex and hippocampus (a) and 24 cell types (derived from single-cell RNA-seq) from 5 different brain regions in mouse (cortex, hippocampus, striatum, midbrain and hypothalamus) and from specific enrichments of oligodendrocytes, serotonergic neurons, dopaminergic neurons and cortical parvalbuminergic interneurons (b). Bar colour indicates whether the cell type is significantly associated with both methods, one method or none. The black vertical line represents the significance threshold corrected for the total number of cell types tested in each analysis. Results obtained for previous iterations of schizophrenia GWAS12,18 are shown for comparison. Pyramidal SS, pyramidal neurons from the somatosensory cortex; pyramidal CA1/CA3, pyramidal neurons from the CA1/CA3 region of the hippocampus. Where types of cell (such as interneurons) formed sub-clusters in the source data, these are designated by the suffix 1 or 2.