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Effects of CUS and treatment with extract (400 mg/kg) on the gene expression of BDNF, TrkB, TLR2, and TLR4 in the hippocampal tissue (a and c) and the prefrontal cortex (b and d). Each point represents the mean ± SEM. * p < 0.05, *** p < 0.001 in comparison with the vehicle group, # p< 0.05, ## p< 0.01, and ### p < 0.001 versus extract 400 group, ^^p < 0.01 and ^^^p < 0.001 compared to CUS+Saline group. CUS: chronic unpredictable stress; Extract: Origanum vulgare L. extract
