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. 2022 Aug 20;79(9):489. doi: 10.1007/s00018-022-04520-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — AhR signaling represents an example of antagonistic pleiotropy in the regulation of the developmental and aging processes. Major beneficial developmental and harmful age-related properties have been listed for comparison. There are some cons for the theory which have been discussed in the text