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. 2022 Aug 20;8:95. doi: 10.1038/s41523-022-00468-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Immune-stimulating microenvironment with homogeneous distribution of CD8+ and CD4+ T cells, M1 polarized macrophages, APC and dendritic cells, in proximity with cancer cells. b Immune-escaping microenvironment with higher ratio of CD68+:CD3+ T cells, and M2 polarized macrophages, and more distance between cancer and immune cells. CD4+and CD8+:Tcells marker; CD68+: pan-macrophage marker; APC: antigen presenting cells; CC: cancer cells; DC: dendritic cells. Figure includes modified templates from Servier Medical Art (smart.servier.com).