Table 4.

Complications and side effects of different treatment modalities.

Therapy	Surgical excision
Side effect	Dry eye	Hyperaemia	Pain	Keratopathy	LSCD	Systemic side effects
Nr. of studies included	1	1	1	1	1	ND
Total nr. of patients	49	49	49	49	49	ND
Side effect rate (%)	59%	38.7%	40.8%	0%	0%	ND

Therapy	IFN
Side effect	Dry eye	Hyperaemia	Pain	Keratopathy	LSCD	Systemic side effects
Nr. of studies included	3	4	2	3	3	2
Total nr. of patients	128	128	97	102	102	54
Side effect rate (%)	34.3%	17.1%	21.6%	0%	0%	12.9%

Therapy	5-FU
Side effect	Dry eye	Hyperaemia	Pain	Keratopathy	LSCD	Systemic side effects
Nr. of studies included	2	2	1	2	2	ND
Total nr. of patients	55	55	54	55	55	ND
Side effect rate (%)	23.6%	21.8%	22.2%	9%	0%	ND

Therapy	MMC
Side effect	Dry eye	Hyperaemia	Pain	Keratopathy	LSCD	Systemic side effects
Nr. of studies included	1	11	ND	1	ND	ND
Total nr. of patients	25	25	ND	25	ND	ND
Side effect rate (%)	36%	44%	ND	12%	ND	ND

LSCD limbal stem cell deficiency.