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. 2022 Aug 20;13:4913. doi: 10.1038/s41467-022-32649-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Left, heatmap depicting the percentage of patients with POU5F1B TcGTs for indicated TCGA cancers and normal tissues of the Genotype–Tissue Expression (GTEx) dataset⁴⁷. Locations of TEs acting as TSS are indicated on top, with the intensity of gray shade proportional to usage frequency. Right, levels of expression of POU5F1B transcripts in 9,566 samples from 32 cancer types of the TCGA dataset and in 8878 samples from 29 normal tissue types of the GTEx dataset. For each TCGA and GTEX category, expression of TcGT samples was compared to non-TcGT samples with a two-sided t-test. Significance levels are shown as stars (*** pval < 0.001, **pval < 0.01, *pval < 0.05). Right margin, percentage of samples with (red) or without TcGT (blue -cancer-, gray -normal tissue–). Abbreviations: ACC adrenocortical carcinoma; BLCA bladder urothelial carcinoma; BRCA breast carcinoma; CESC cervical squamous cell carcinoma; CHOL cholangiocarcinoma; COAD colon adenocarcinoma; DLBC diffuse large B-cell lymphoma; ESCA esophageal carcinoma; GBM glioblastoma multiforme; HNSC head, and neck squamous cell carcinoma; KICH kidney chromophobe; KIRC kidney renal clear cell carcinoma; KIRP kidney renal papillary cell carcinoma; LAML acute myeloid leukemia; LGG low grade glioma; LIHC liver hepatocellular carcinoma; LUAD lung adenocarcinoma; LUSC lung squamous cell carcinoma; MESO mesothelioma; OV ovarian cancer; PAAD pancreatic adenocarcinoma; PCPG pheochromocytoma, and paraganglioma; PRAD prostate adenocarcinoma; READ rectal adenocarcinoma; SARC sarcoma; SKCM skin cutaneous melanoma; STAD stomach adenocarcinoma; THCA thyroid carcinoma; THYM thymoma; UCEC uterine corpus endometrial carcinoma; UCS uterine carcinosarcoma; UVM uveal melanoma.