Table 2.
Comparison of the changes from baseline in overactive bladder symptoms, heart rate variability cardio-ankle vascular index and ankle-brachial pressure index after 12-week treatment between the mirabegron and solifenacin groups.
| Variable | Mirabegron (n = 43)† | Solifenacin (n = 44)† | P‡ |
|---|---|---|---|
| OABSS | |||
| Daytime frequency | 0 (− 1, 0)** | 0 (− 1, 0)** | 0.23 |
| Nocturia | 0 (− 1, 0)** | 0 (− 1, 0)* | 0.17 |
| Urgency | − 1 (− 3, 0)** | − 1 (− 3, 0)** | 0.71 |
| Urgency incontinence | 0 (− 1, 0)* | − 1 (− 2, 0)** | 0.11 |
| OABSS total score | − 3 (− 5, − 1)** | − 3 (− 5, − 1)** | 0.75 |
| SDNN (ms) | − 1.9 (− 11.4, 5.4) | 1.2 (− 5.4, 6.1) | 0.14 |
| RMSSD (ms) | − 2.1 (− 12.5, 6.5) | 0.0 (− 5.5, 9.0) | 0.29 |
| NN50 | 0 (− 5.5, 2.5) | 0 (− 5.1, 4.4) | 0.81 |
| pNN50 (%) | 0 (− 2.2, 0.8) | 0 (− 0.7, 2.5) | 0.26 |
| SD1 | − 1.5 (− 8.8, 4.6) | 0.0 (− 3.9, 6.5) | 0.27 |
| SD2 | − 5.3 (− 17.8, 5.7) | 0.8 (− 7.7, 8.6) | 0.14 |
| SD1/SD2 | − 0.01 (− 0.14, 0.14) | 0.01 (− 0.06, 0.14) | 0.44 |
| VLF(ms2) | − 53 (− 138.5, 81) | 15.8 (− 72.3, 67.8) | 0.12 |
| LF (ms2) | − 2 (− 96.5, 41) | − 0.8 (− 22.4, 89.8) | 0.33 |
| HF (ms2) | − 3 (− 125, 52.5) | 2.8 (− 51.9, 200.8) | 0.23 |
| Total Power (ms2) | − 35.5 (− 432, 185.5) | 6.3 (− 146.1, 509.5) | 0.20 |
| LF norm (n.u.) | 0.4 (− 12.3, 8.7) | − 3.0 (− 10.5, 9.0) | 0.71 |
| HF norm (n.u.) | − 0.4 (− 8.7, 12.3) | 3.0 (− 9.0, 10.6) | 0.70 |
| LF/HF | 0.02 (− 0.48, 0.25) | − 0.13 (− 0.45, 0.25) | 0.89 |
| SBP of right brachial artery (mmHg) | 0 (− 12, 7) | − 5.5 (− 14.8, 1.3)** | 0.09 |
| DBP of right brachial artery (mmHg) | − 0.5 (− 5.3, 6) | − 3 (− 7, 3)* | 0.24 |
| SBP of left brachial artery (mmHg) | 0 (− 6.3, 8.3) | − 4.5 (− 13.8, 5)* | 0.13 |
| DBP of left brachial artery (mmHg) | − 2 (− 7.3, 3) | − 3.5 (− 10.8, 2)** | 0.25 |
| SBP of right ankle artery (mmHg) | 0 (− 10.5, 7.3) | − 4.5 (− 10.8, 4.8)* | 0.33 |
| DBP of right ankle artery (mmHg) | 0.5 (− 4, 3) | − 0.5 (− 8.8, 4.8) | 0.71 |
| SBP of left ankle artery (mmHg) | − 2 (− 9, 4.8) | − 5.5 (− 16.8, 4.8)* | 0.21 |
| DBP of left ankle artery (mmHg) | − 1 (− 5, 2) | − 1 (− 7.8, 4.5) | 0.17 |
| Heart rate (per min) | 2 (− 2.3, 7)* | 1 (− 4, 7) | 0.49 |
| CAVI | − 0.05 (− 0.44, 0.40) | − 0.05 (− 0.69, 0.66) | 0.88 |
| ABI | 0.01 (− 0.05, 0.05) | 0.00 (− 0.04, 0.05) | 0.99 |
Data are expressed as median (interquartile range). Changes from baseline are the subtraction of pretreatment values from posttreatment values. Abbreviations are as in Table 1.
†Within-group comparisons of baseline and posttreatment values were performed by Wilcoxon signed-rank test. *p < 0.05, and **p < 0.01.
‡Wilcoxon rank-sum test.