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. 2022 Aug 20;13(8):726. doi: 10.1038/s41419-022-05170-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Analysis of USP10 differentially gene expression level of GSE5281. b The level of USP10 in the postmortem hippocampus brain was measured by western blotting (WB). c Densitometry of WB shows a significant increase in AD compared to control. n = 6 control and 7 AD. d Immunofluorescence staining of USP10 in 13-month APP/PS1 mice. Scale bar = 500 μm. e, f The level of USP10 was significantly increased in the hippocampus of 6-month-old APP/PS1 mice, n = 8. g, h USP10 and Tau5 were detected in the hippocampus of 6-month-old P301S mice; n = 3. All data represent mean ± SEM, p-value significance is calculated from an unpaired two-tailed t-test. *P < 0.05, ***P < 0.001, ****P < 0.0001 vs control.