FIGURE 1.

miR-212-3p was weakly expressed in AD rats and miR-212-3p overexpression improved neurological functions of AD rats. The AD rat model was established through injection of Aβ1-42, followed by the treatment of miR-212-3p agomir. (A) miR-212-3p expression in the hippocampus was detected through RT-qPCR; (B-D) animal’s learning and memory capacities were assessed through MWMT; (E and F) morphology and functions of neurons were observed through H&E staining (E) and Nissl’s staining (F). N=6. Data were formalized as mean ± SD. Data in Figures A and C-F were analyzed using one-way ANOVA, and data in Figure B were analyzed using two-way ANOVA, followed by Tukey’s multiple comparison test.