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Molecular mechanism of miR-212-3p in AD-induced neuroinflammation. SP1 bounds to the BACE1 promoter region to activate BACE1 expression. miR-212-3p inhibited SP1 and then BACE1 to block the activation of the NLRP3/Caspase-1 signaling pathway, thus attenuating neuroinflammation in AD rats.
